Antabuse (disulfiram)

Antabuse (Disulfiram) is a modern highly effective drug for treatment of alcoholic addiction. It works by increasing sensitivity to alcohol, providing alcohol intolerance when alcohol addiction is decreased. Alcohol consumption becomes physically impossible.

Initially, an active component was used at rubber manufacturing. It has been noticed that among employees at rubber manufacture factories there were fewer alcoholics. Antabuse was investigated and started to be applied in the medical purposes from the end of 40s.

In spite of the fact that Antabuse is not a new drug, being used in medicine over 60 years, it is still a modern drug as it is successfully used till now. Now it is possible to buy Antabuse in any country of the world. Antabuse efficacy has been investigated during many clinical trials. Drug properties and high efficacy are considered to be the best.

Antabuse has been proved as an efficient remedy allowing to achieve alcoholism treatment. Antabuse is prescribed in treatment and prophylaxis of chronic alcoholism.

The shape, color and label of the pills depends on the manufacturer. These pills are the same chemically and since the active ingredient is identical, they have the same medical effect.

Generic Antabuse is supplied in the forms of effervescent tablets. These tablets are octagonal-shaped. For example, this is a Generic Antabuse pills 250mg:

Generic Antabuse - 250mg

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Also Disulfiram is supplied in the forms of white effervescent tablets, rounded, flatted, with imprinted “CD” on one side and “C” on another side, or cross-wised on one side, dividing a tablet into four parts, and with imprinted “CJ”.

Disulfiram

Antabuse is a very drastic medication. The patients are recommended to consider seriously the treatment with this medication. Self-treatment with Antabuse is strictly prohibited as the treatment may cause adverse reactions.

The patients have to consult the doctor before Antabuse use. The doctor will define your diagnosis and will decide, whether it Antabuse use is suitable for your case, and then, taken into consideration the drug effect on your organism, will indicate the right treatment course which should be adhered throughout the whole drug course.

Before Antabuse prescription, the patient should pass the psychotherapeutic conversation explaining the mechanism of drug action, danger of alcohol consumption while drug use. Before Antabuse treatment, the patient or his relatives are asked to sign the document indicating that the patient bears responsibility for all possible risks to his health and life if he fails to follow the doctor’s recommendation to avoid alcohol consumption during the treatment. Except legal, this informed consent has also psychotherapeutic effect. It is attached to the case record.
 
Evidently, Antabuse is a drastic medication which can be dangerous if used improperly. But you should not worry, as the treatment with Antabuse is conducted under doctor’s observance, nothing dangerous may occur; only alcoholism will be treated. Antabuse has been used in medicine for many years, and up to now it is considered to be one of the most used. Antabuse is characterized by perfect effect and treats alcoholism very quickly and effectively.
 
Antabuse is taken orally. An effervescent tablet is placed in water, about half of glass, till full drug dissolution. Treatment should be started only after the patient’s examination and revealing of all aspects of this process. The dosage is prescribed individually to every patient, depending on disease severity and health state. Usually, an average dose is up to 200–500mg once or twice a day.

Approximately in 7–10 days of the treatment, disulfiram-alcohol test is made (20–30ml of alcohol after taking 500mg of the drug), if reaction is weak, an alcohol dose is increased by 10–20ml (maximum alcohol dose is 100-120ml).

Test is performed again in 1–2 days at hospital and in 3–5 days outpatiently with alcohol or drug doses adjustment, if required. Further a supporting dose of 150-200mg a day within 1–3 years can be maintained.

After peroral taking, 70 to 90% of tetraethylthiuram disulfide is absorbed in the gastrointestinal tract, quickly metabolized and eliminated through the lungs.

Antabuse affects alcohol consumption changing metabolism. Ethyl spirit is transformed into aldehyde by dehydrogenase enzyme in the liver, and then, into acetate by oxidoreductase enzyme.

When Antabuse is taken, alcohol is turned into aldehyde that cannot be turned into acetate. Aldehyde is accumulated, causing toxic effects, as hyperemia of face, tachycardia, nausea and vomiting, headache, short breath. These unpleasant reactions are supposed to help the patient to abstain from alcohol.

It leads to conditioned-reflex disgust at alcohol taste and smell. After the treatment with Antabuse, alcohol consumption causes acute vascular reaction. Gradually, reaction is disappeared and, in 1-2 hours, the patient falls asleep.

After high doses of alcohol consumption, adverse reaction, such as pallor of integuments, cyanosis, vomiting, high palpitation, drop in arterial pressure, myocardial ischemia may be experienced.

Evidently, Antabuse is a drastic medication powerfully solving alcohol problem.

Contraindications to drug application are recommended to be thoroughly studied as the doctor prescribes the drug taking into consideration them. Contraindications and health state are considered for correct prescription to provide the safety of the treatment course with Antabuse.

Contraindications include: serious cardiovascular diseases, disorders of organs of hearing, glaucoma, optic nerve neuritis, bronchial asthma, emphysema of lungs, tuberculosis, serious hepatic impairment, blood-forming disorder, diabetes, mental diseases, stomach ulcer, malignant tumours, and also intolerance of any drug component.

Also, Antabuse is forbidden during pregnancy and breast-feeding as the drug may negatively affect a fetus and an infant during breast-feeding.

Ascorbic acid and certain other medications, such as peroral anticoagulants, teophylline, phenitoin and others should not be taken with Antabuse.

Side-effects are a negative side of all medications, but they cannot be avoided during the treatment. Each organism responses individually to certain drug components, therefore, symptoms of side-effects may vary.

Drug manufacturers try to reduce side-effects, thence, they are observed very seldom, however, they have been reported. Side-effects may include: metallic taste in the mouth, hepatitis, polyneuritis of the legs, optic nerve neuritis, memory loss, mental confusion, asthenia, headaches, skin itching.

But usually side-effects are insignificant; they pass soon, without negative influence on health. In case of symptoms of any side-effects, visit your doctor. He may adjust the drug dose, or undertake certain actions.

Antabuse helped millions of people suffering from alcoholism worldwide. It is a highly effective drug characterized by excellent action, relieving from alcohol addiction. So, do not hesitate to start the treatment, and buy Antabuse to get rid of this horrible disease.